بررسی اثر سیکلوسپورین موضعی بر لیکن پلان دهانی

Background & Objective : as there are many different ways for treatment of oral lichen planus, and there may be many relapses in its course, and conflicting reports of therapeutic effects of many drugs and for determining the effect of topical cyclosporin oral solution on oral lesions of lichen planus, this investigation was performed in Hamadan, Sina hospital at 1375. (1996). Methods & Materials : In a quasi experimental study, we treated 15 patients with severe oral lichen planus who came to the clinic sequentially. Clinical diagnosis was donne on the basis of the presence of symptoms (burning mucosal lesions) and the reticular, erosive and erythemteous lesions. After doing biopsy of the lesions, diagnosis was confirmed by microscopic examination. The severity of mucosal lesions was determined on the basis of the extent of mucosal involvemnet and degree of burning sensation. Mucosal lesions were classified as severe, moderate or mild. We treated patients with 1 ml of topical cyclosporin solusion 100 mg/ml with a seish-and-spit method three time daily. The duration of treatment was 6 weeks. Thereafter, the patients were followed for a minimum of months. Results: the patients were 6 women and 9 men, with the range of 45 + 12 years of age. They had oral lichen planus for a mean period of 3 years. Two week after starting treatment, the mucosal lesions were changed from a severe form to the moderate form in 9 patients (60%). In three patients, the mucosal lesions were changed from the sever to the mild form (20%), and in three patients remained in the sever form (20%). At the end of the fourth week, mucosal lesions were completely resolved in four patients (26.6%). Six patients had the mild forms (40%), and five patients (33.3%) had moderate lesions. At the end of the 6 weeks, eleven patients were completely resolved of mucosal lesions (73.4%). Mucosal lesions remained in the mild form in four patients (26.6%). The patients were followed up once monthly for six months. There was not seen any recurrence in the resolved patients. The above mentioned mucosal lesions of the four patients remained in the mild form after six months. Conclusion: Our study showed that in comparison with the transient therapeutic effects of the topical corticosteroids, topical cyclosporin has more beneficial and longstanding therapeutic effects on oral lesions of lichen planus.